AskDefine | Define cornification

User Contributed Dictionary



  1. Conversion into, or formation of, horn; a becoming like horn.

Extensive Definition

Cornification is the process of forming an epidermal barrier in stratified squamous epithelial tissue.
At cellular level cornification is characterised by
  • production of keratin
  • production of small proline-rich (SPRR) proteins and transglutaminase which eventually form a cornified cell envelope beneath the plasma membrane
  • terminal differentiation
  • loss of nuclei and organelles, in the final stages of cornification metabolism ceases and the cells are completely filled by keratin
Sources: and .


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