- Conversion into, or formation of, horn; a becoming like horn.
Cornification is the process of forming an epidermal barrier in stratified squamous epithelial tissue.
At cellular level cornification is characterised by
- production of keratin
- production of small proline-rich (SPRR) proteins and transglutaminase which eventually form a cornified cell envelope beneath the plasma membrane
- terminal differentiation
- loss of nuclei and organelles, in the final stages of cornification metabolism ceases and the cells are completely filled by keratin
Sources: and .